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Get report file from metaboanalyst1/6/2024 The obese asthma group was defined as having obesity with BMI ≥ 30.0 kg/m 2, and the lean asthma group was defined as having normal weight between 18.5 and 25 kg/m 2 according to the World Health Organization. This cross-sectional study assessed eligible patients with obese asthma (n = 11) and lean asthma (n = 22) who were recruited from the Asthma Clinic of West China Hospital, Sichuan University between August 2015 and February 2016. 19 20 Therefore, it is more plausible to examine the metabolic alterations in the peripheral blood and sputum of asthmatics with obesity to improve understanding of the molecular pathophysiologic mechanism. 18 Moreover, obesity is well known as a status of low-grade inflammation both systemically and in the lungs. Probably, it is more difficult to obtain a reliable interpretation and correlation of these metabolites with the disease based on EBC sample, and it can be more justified with the use of bronchoalveolar lavage fluid (BALF), or induced sputum for exploratory studies that aimed at obtaining a close molecular mechanism of a respiratory disease. However, like most of the other metabolomics studies, 17 it just reported metabolic profiles in the exhaled breath condensate (EBC) and did not explore further correlations between relevant metabolites and clinical characteristics or inflammation biomarkers. 16 In fact, the previous study has produced promising results in defining a distinct obesity-asthma metabotype. To the best of our knowledge, there is only 1 metabolomics study exploring the pathophysiologic mechanisms of obese asthma. 9 It has also been proved that obesity is associated with worse clinical outcomes and decreased response to asthma medication, 8 “Obese asthma” phenotype has been identified in unbiased cluster analyses, 10 but the underlying mechanisms remain poorly understood. 7 Epidemiological studies have shown that obesity is associated with increased risk of incident asthma 8 and other allergic diseases. 6 Obesity is also a major public health concern, whose prevalence has dramatically and concurrently increased with asthma over the last decades. 1 2 3 4 Although there is a positive declining trend for asthma mortality, 5 asthma plus allergic rhinitis is the most frequently diagnosed multiple respiratory disorders, which has a significant impact on disease burden across the Asia-Pacific region. ![]() Asthma is one of the most common chronic respiratory diseases affecting 1%–18% of the population in different countries, which is characterized by chronic airway inflammation with underlying heterogeneous inflammatory mechanisms that result in multiple clinical phenotype.
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